Hydrochloric Acid → HCID 66662352, compound

HRID 2275677Notes

Reaction equation

HRID 2275677 reaction equation
[CH3:1][C:2]1([CH3:19])[C:6]2([CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7]2)[O:5][C:4](=[O:18])[CH2:3]1.[ClH:20]>O1CCOCC1>[ClH:20].[CH3:1][C:2]1([CH3:19])[C:6]2([CH2:10][CH2:9][NH:8][CH2:7]2)[O:5][C:4](=[O:18])[CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66662118HCID 66662118, compound

Product 1

HCID 66662352HCID 66662352, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl 4,4-dimethyl-2-oxo-1-oxa-7-azaspiro[4,4]nonane-7-carboxylate (0.20 g, 0.00074 mol) was treated with hydrogen chloride in 1,4-dioxane (4.00 M, 5.00 mL) at rt for 2 h. The volatiles were removed in-vacuo and the resultant HCl salt was used directly in the next step without further purification. LCMS (M+H) 170.2.

Workup

  1. customThe volatiles were removed in-vacuo
  2. customthe resultant HCl salt was used directly in the next step without further purification

Sources & evidence

ORD record
ord-4597b1e8f5e64d65a1ad8b83934dd6dc
Source dataset
uspto-grants-2015_09
Patent number
US09126927B2

Reaction notes

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