反应详情

温度

100 °C

A mixture of 3-methoxy-6-(tetrahydroquinoline-1-sulfonyl)-pyridazine (1.14 mmol, 112 mg), conc. HCl (2 mL), and dioxane (5 mL) was heated at 100° C. for two hours. The reaction mixture was cooled and evaporated to dryness. Water (10 mL) was added to the residue and extracted with EtOAc. The EtOAc extract was washed with water, collected, dried, filtered and the filtrate was evaporated to a residue, which was crystallized from ether to yield 6-(tetrahydroquinoline-1-sulfonyl)-2H-pyridazin-3-one (33%, 11 mg); mp 200° C.

1. temperatureThe reaction mixture was cooled
2. customevaporated to dryness
3. additionWater (10 mL) was added to the residue
4. extractionextracted with EtOAc
5. extractionThe EtOAc extract
6. washwas washed with water
7. customcollected
8. customdried
9. filtrationfiltered
10. customthe filtrate was evaporated to a residue, which
11. customwas crystallized from ether