HCID 57437974, compound → Ethyl 4-amino-5-methylpyridine-3-carboxylate

HRID 227576Notes

Reaction equation

HRID 227576 reaction equation
[N:1]([C:4]1[C:9]([CH3:10])=[CH:8][N:7]=[CH:6][C:5]=1[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[N+]=[N-].[H][H]>C(O)C.[Pd]>[NH2:1][C:4]1[C:9]([CH3:10])=[CH:8][N:7]=[CH:6][C:5]=1[C:11]([O:13][CH2:14][CH3:15])=[O:12]

Participants

5

Reactant 2

HCID 57437974HCID 57437974, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 46735270Ethyl 4-amino-5-methylpyridine-3-carboxylateYield 98.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

0.50 g of material prepared in Step A was dissolved in 15 mL of ethanol. 0.15 g of 10% palladium on carbon was added. The reaction mixture was placed under one atmosphere of hydrogen for 2 hours. The catalyst was removed by filtration. The solvent was removed with a rotary evaporator to afford 0.43 g of the title compound as a white solid.

Workup

  1. customThe catalyst was removed by filtration
  2. customThe solvent was removed with a rotary evaporator

Sources & evidence

ORD record
ord-476daa395cd641c88469a6ece3beb246
Source dataset
uspto-grants-2009_07
Patent number
US07560564B2

Reaction notes

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