Lithium Hydroxide → HCID 86717888, 화합물

HRID 2275776노트

반응식

HRID 2275776 반응식
[CH:1]1([C:4]2[N:5]=[C:6]3[C:11]([O:12][CH2:13][C:14]4[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=4[F:21])=[CH:10][CH:9]=[CH:8][N:7]3[C:22]=2[C:23]([O:25]CC)=[O:24])[CH2:3][CH2:2]1.[OH-].[Li+]>CO.C1COCC1>[CH:1]1([C:4]2[N:5]=[C:6]3[C:11]([O:12][CH2:13][C:14]4[C:15]([F:21])=[CH:16][CH:17]=[CH:18][C:19]=4[F:20])=[CH:10][CH:9]=[CH:8][N:7]3[C:22]=2[C:23]([OH:25])=[O:24])[CH2:2][CH2:3]1

참가 물질

4

반응물 2

HCID 3939Lithium Hydroxide2회HCID 86717887HCID 86717887, 화합물

생성물 1

HCID 86717888HCID 86717888, 화합물

시약·촉매·용매 1

HCID 21899815MeOH tetrahydrofuran용매

실험 절차

410 mg of ethyl 2-cyclopropyl-8-[(2,6-difluorobenzyl)oxy]imidazo[1,2-a]pyridine-3-carboxylate (Example 24A, 1.1 mmol, 1 equivalent) were initially charged in 15 ml of methanol/THF (1:1), and 5.5 ml of a 1 N aqueous lithium hydroxide solution (5.5 mmol, 5 equivalents) were added. The reaction mixture was stirred at RT overnight. Another 5.5 ml of 1 N aqueous lithium hydroxide solution were added, and the mixture was stirred at RT for another night. The mixture was then concentrated under reduced pressure and the residue was taken up in water and acidified with 1 N aqueous hydrochloric acid. The precipitated product was filtered off and dried under high vacuum. This gave 293 mg (77% of theory) of the title compound.

후처리

  1. stirringthe mixture was stirred at RT for another night
  2. concentrationThe mixture was then concentrated under reduced pressure
  3. filtrationThe precipitated product was filtered off
  4. customdried under high vacuum

출처 및 근거

ORD 기록
ord-05d2f344695847c4882a181caa06902c
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09126998B2

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