Sodium Hydroxide → HCID 67181984, compound

HRID 227580Notes

Reaction equation

HRID 227580 reaction equation
[NH2:1][C:2]1[C:3]([C:9]([O:11]C)=[O:10])=[N:4][CH:5]=[N:6][C:7]=1[CH3:8].[OH-].[Na+:14]>CO>[Na+:14].[NH2:1][C:2]1[C:3]([C:9]([O-:11])=[O:10])=[N:4][CH:5]=[N:6][C:7]=1[CH3:8]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 45082623Methyl 5-amino-6-methylpyrimidine-4-carboxylate

Product 1

HCID 67181984HCID 67181984, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.0 g (12 mmol) of the material from Step E was dissolved in 24 mL of methanol. 12 mL of 1N solution of sodium hydroxide was added. After 1 hour the solvent was removed with a rotary evaporator. The residue was dried in a vacuum oven overnight to afford 2.39 g of the title compound as a tan solid.

Workup

  1. customAfter 1 hour the solvent was removed with a rotary evaporator
  2. customThe residue was dried in a vacuum oven overnight

Sources & evidence

ORD record
ord-a18f5eba47124dc4a61e54ba6defff76
Source dataset
uspto-grants-2009_07
Patent number
US07560564B2

Reaction notes

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