Hydrochloric Acid → HCID 86717902, compound

HRID 2275826Notes

Reaction equation

HRID 2275826 reaction equation
[ClH:1].C(OCC)C.[F:7][C:8]1([F:23])[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][NH:15]C(=O)OC(C)(C)C)[CH2:9]1>>[ClH:1].[ClH:1].[F:7][C:8]1([F:23])[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][NH2:15])[CH2:9]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 86717900HCID 86717900, compound

Product 1

HCID 86717902HCID 86717902, compound

Procedure

8.6 ml of a 2 N solution of hydrogen chloride in diethyl ether (17.22 mmol, 10 equivalents) were added to 431 mg of tert-butyl [2-(3,3-difluoropyrrolidin-1-yl)ethyl]carbamate (Example 164A, 1.72 mmol, 1 equivalent), and the reaction mixture was stirred at RT overnight. The solvent was then decanted off, the residue was triturated three times with diethyl ether and the residue obtained in this manner was dried under reduced pressure. This gave 410 mg (99% of theory; purity 93%) of the title compound.

Workup

  1. customThe solvent was then decanted off
  2. customthe residue was triturated three times with diethyl ether
  3. customthe residue obtained in this manner
  4. customwas dried under reduced pressure

Sources & evidence

ORD record
ord-4f483dd978ae471f9e8a3cfba1c33ecd
Source dataset
uspto-grants-2015_09
Patent number
US09126998B2

Reaction notes

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