Hydrochloric Acid → 1609345-54-1

HRID 2275827Notes

Reaction equation

HRID 2275827 reaction equation
[ClH:1].C(OCC)C.[CH3:7][O:8][CH2:9][CH2:10][NH:11][CH2:12][CH2:13][NH:14]C(=O)OC(C)(C)C>>[ClH:1].[ClH:1].[CH3:7][O:8][CH2:9][CH2:10][NH:11][CH2:12][CH2:13][NH2:14]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 45092295HCID 45092295, compound

Product 1

HCID 867179031609345-54-1

Procedure

15.5 ml of a 2 N solution of hydrogen chloride in diethyl ether (31 mmol, 10 equivalents) were added to 750 mg of tert-butyl {2-[(2-methoxyethyl)amino]ethyl}carbamate (Example 165A, purity about 90%, 3.1 mmol, 1 equivalent), and the mixture was stirred at RT overnight. The solvent was decanted off, the residue was triturated three times with diethyl ether and the product obtained in this manner was dried under reduced pressure. This gave 482 mg (82% of theory) of the title compound.

Workup

  1. customThe solvent was decanted off
  2. customthe residue was triturated three times with diethyl ether
  3. customthe product obtained in this manner
  4. customwas dried under reduced pressure

Sources & evidence

ORD record
ord-dde0e1bf808945099bb00b699d33bda2
Source dataset
uspto-grants-2015_09
Patent number
US09126998B2

Reaction notes

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