Hydrochloric Acid → 1609345-55-2

HRID 2275828Notes

Reaction equation

HRID 2275828 reaction equation
[ClH:1].C(OCC)C.[F:7][C:8]1([F:24])[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][NH:16]C(=O)OC(C)(C)C)[CH2:10][CH2:9]1>>[ClH:1].[ClH:1].[F:24][C:8]1([F:7])[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][NH2:16])[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 86717901HCID 86717901, compound

Product 1

HCID 867179041609345-55-2

Procedure

6.9 ml of a 2 N solution of hydrogen chloride in diethyl ether (13.8 mmol, 10 equivalents) were added to 500 mg of tert-butyl [2-(4,4-difluoropiperidin-1-yl)ethyl]carbamate (Example 166A, 1.38 mmol, 1 equivalent), and the mixture was stirred at RT overnight. The solvent was decanted off, the residue was triturated three times with diethyl ether, the diethyl ether was decanted off and the product obtained in this manner was dried under reduced pressure. This gave 448 mg (100% of theory; purity 73%) of the title compound.

Workup

  1. customThe solvent was decanted off
  2. customthe residue was triturated three times with diethyl ether
  3. customthe diethyl ether was decanted off
  4. customthe product obtained in this manner
  5. customwas dried under reduced pressure

Sources & evidence

ORD record
ord-46cff41c013844bbbb50f827e2a10450
Source dataset
uspto-grants-2015_09
Patent number
US09126998B2

Reaction notes

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