Hydrochloric Acid → HCID 90114173, compound

Under argon, 218 mg (0.71 mmol, 87% pure) rac-benzyl (2-amino-3-isopropoxypropyl)carbamate from Example 76A were initially charged in ethanol (5.0 ml), and 76 mg (0.07 mmol) of 10% palladium on activated carbon and 2.2 ml (21.36 mmol) of cyclohexene were added. The reaction mixture was stirred under reflux overnight. The mixture was then filtered through a Millipore® filter, the filter cake was washed with ethanol, 0.7 ml (1.42 mmol) of 2 M hydrogen chloride in diethyl ether were added to the filtrate and the mixture was concentrated and dried under high vacuum. This gave 190 mg (99% of theory, purity 76%) of the target compound.

1. temperatureunder reflux overnight
2. filtrationThe mixture was then filtered through a Millipore®
3. filtrationfilter
4. additionwere added to the filtrate
5. concentrationthe mixture was concentrated
6. customdried under high vacuum

ORD record

ord-2b249267ac4a4cc08e2f4832b4ca8770

Source dataset

uspto-grants-2015_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09126998B2