反应详情

To a solution of 1 g (7.25 mmol) of 3-amino-4-pyridinecarboxylic acid in 5 mL of ethyl alcohol was added 2 mL of sulfuric acid. The mixture was warmed under reflux for 2 h. It was cooled and basified with conc. NH4OH solution to pH=8. The resulting solution was extracted with ethyl acetate and the organic layer was washed with brine and water, dried (MgSO4) and concentrated in vacuo to give 1.04 g of the title compound as a white solid (87%).

1. temperatureThe mixture was warmed
2. temperatureunder reflux for 2 h
3. temperatureIt was cooled
4. extractionThe resulting solution was extracted with ethyl acetate
5. washthe organic layer was washed with brine and water
6. dry with materialdried (MgSO4)
7. concentrationconcentrated in vacuo