Hydrochloric Acid → HCID 90114648, compound

HRID 2275875Notes

Reaction equation

HRID 2275875 reaction equation
[ClH:1].[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([NH:19][C:20]([C:22]2[N:26]3[CH:27]=[CH:28][CH:29]=[C:30]([O:31][CH2:32][C:33]4[C:38]([F:39])=[CH:37][CH:36]=[CH:35][C:34]=4[F:40])[C:25]3=[N:24][C:23]=2[CH3:41])=[O:21])[CH2:10][NH:11]C(=O)OC(C)(C)C)=[CH:5][CH:4]=1>C(OCC)C>[ClH:2].[ClH:1].[NH2:11][CH2:10][CH:9]([NH:19][C:20]([C:22]1[N:26]2[CH:27]=[CH:28][CH:29]=[C:30]([O:31][CH2:32][C:33]3[C:38]([F:39])=[CH:37][CH:36]=[CH:35][C:34]=3[F:40])[C:25]2=[N:24][C:23]=1[CH3:41])=[O:21])[C:6]1[CH:5]=[CH:4][C:3]([Cl:2])=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 90135983HCID 90135983, compound

Product 1

HCID 90114648HCID 90114648, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

3.5 ml (7.0 mmol) of a 2 M solution of hydrochloric acid in diethyl ether were added to 396 mg of rac-tert-butyl {2-(4-chlorophenyl)-2-[({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]-pyridin-3-yl}carbonyl)amino]ethyl}carbamate (Example 78A, 0.69 mmol), and the mixture was stirred at RT for 5.5 h. The resulting precipitate was filtered off, washed with diethyl ether and dried under high vacuum. This gave 341 mg of the title compound (90% of theory).

Workup

  1. filtrationThe resulting precipitate was filtered off
  2. washwashed with diethyl ether
  3. customdried under high vacuum

Sources & evidence

ORD record
ord-63f74a4ab5054bb59e40cc61f411c1e2
Source dataset
uspto-grants-2015_09
Patent number
US09126998B2

Reaction notes

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