Hydrochloric Acid → HCID 20316401, compound

HRID 227590Notes

Reaction equation

HRID 227590 reaction equation
[C:1]([C:3]1[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=[CH:5][N:4]=1)#N.[OH-:13].[K+].Cl.[OH2:16]>>[CH3:10][O:9][C:8]1[C:3]([C:1]([OH:16])=[O:13])=[N:4][CH:5]=[CH:6][C:7]=1[O:11][CH3:12]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 17966448HCID 17966448, compound

Product 1

HCID 20316401HCID 20316401, compound

Procedure

1 g of 3,4-dimethoxy-2-cyanopyridine obtained in Example e) and 3.5 g of potassium hydroxide in 15 ml of water are heated to 85° C. for half an hour. It is allowed to cool and in an ice bath hydrochloric acid is added gently to pH=2-3. After concentration to dryness, the residue is extracted three times with hot methanol, allowed to cool, filtered and concentrated. There is obtained a solid used crude.

Workup

  1. additionis added gently to pH=2-3
  2. concentrationAfter concentration to dryness
  3. extractionthe residue is extracted three times with hot methanol
  4. temperatureto cool
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customThere is obtained a solid used crude

Sources & evidence

ORD record
ord-db39a970a5d344c38f5f9a96ea430995
Source dataset
uspto-grants-2009_07
Patent number
US07560565B2

Reaction notes

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