反应详情

50 g of bromo-9,9-dimethyl-9H-fluorene (183 mmol), 20 ml of aniline (220 mmol), 1.5 g of DPPF (2.7 mmol), 0.5 g of palladium(II)acetate and 45 g of sodium tert-butoxide (486 mmol) are heated at the boil in 1.5 l of toluene under a protective atmosphere for 18 h. The mixture is subsequently partitioned between toluene and water, and the organic phase is washed three times with water and dried over Na2SO4 and evaporated in a rotary evaporator. The residue which remains is recrystallised from heptane/ethyl acetate. The yield is 31.2 g (110 mmol, 52%).

1. customThe mixture is subsequently partitioned between toluene and water
2. washthe organic phase is washed three times with water
3. dry with materialdried over Na2SO4
4. customevaporated in a rotary evaporator
5. customThe residue which remains is recrystallised from heptane/ethyl acetate