Succinic anhydride → HCID 86667395, compound

HRID 2275984Notes

Reaction equation

HRID 2275984 reaction equation
[C:1]1(=[O:7])[O:6][C:4](=[O:5])[CH2:3][CH2:2]1.[CH2:8]([C:11]#[N:12])[CH2:9][OH:10]>C1(C)C=CC=CC=1>[C:11]([CH2:8][CH2:9][O:10][C:4](=[O:5])[CH2:3][CH2:2][C:1]([OH:6])=[O:7])#[N:12]

Participants

4

Reactant 2

HCID 7922Succinic anhydrideHCID 8011Hydracrylonitrile

Product 1

HCID 86667395HCID 86667395, compoundYield 101.8%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

5.00 g (50 mmol) of succinic anhydride, 3.55 g (50 mmol) of ethylene cyanohydrin and 61 mg (0.5 mmol) of N,N-dimethylaminopyridine were dissolved in 40 mL of toluene, and heated under reflux for 10 hours. After the reaction, the reaction liquid was concentrated under reduced pressure to give 8.71 g of 4-(2-cyanoethoxy)-4-oxobutanoic acid as a mixture.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 10 hours
  3. customAfter the reaction
  4. customthe reaction liquid
  5. concentrationwas concentrated under reduced pressure

Sources & evidence

ORD record
ord-f5af01437f1c446d910e308bccc1e2fc
Source dataset
uspto-grants-2015_09
Patent number
US09130244B2

Reaction notes

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