HRID2276111

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2155

2-Aminothiazole

C3H4N2S

HCID73895

Benzene, 1-fluoro-2-nitro-

C6H4FNO2

HCID80651

Methyl 3-methoxysalicylate

C9H10O4

HCID66998812

未命名化合物

2 次

PRODUCTS

生成物

结构：COC(=O)c1cccc(OC)c1Oc1ccccc1NC(=O)Nc1nccs1

HCID59732930

未命名化合物

收率 72%

结构：COC(=O)c1cccc(OC)c1Oc1ccccc1[N+](=O)[O-]

HCID66998767

未命名化合物

收率 82%

PROCEDURE

实验过程

2-(2-Methoxy-6-methoxycarbonylphenoxy)-1-nitrobenzene (1.24 g, 82%) was prepared from methyl 3-methoxysalicylate (1.0 g, 5.5 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This compound was reduced to 2-(2-methoxy-6-methoxycarbonylphenoxy)aniline (0.89 g, 80%) following the general procedure C. N-[2-(2-Methoxy-6-methoxycarbonylphenoxy)phenyl]-N′-(thiazol-2-yl)urea (143 mg, 72%) was prepared from 2-(2-methoxy-6-methoxycarbonylphenoxy)aniline (136 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-89392c629fc24ed6a20f4ac1546fb11b
来源数据集: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: USRE045670E1
来源说明: uspto-grants-2015_09

反应 SMILES

[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:5]([C:6]([O:8][CH3:9])=[O:7])[C:4]=1[OH:13].F[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N+:21]([O-:23])=[O:22].[CH3:24][O:25][C:26]1[CH:39]=[CH:38][CH:37]=[C:36]([C:40]([O:42][CH3:43])=[O:41])[C:27]=1[O:28][C:29]1[CH:35]=[CH:34][CH:33]=[CH:32][C:30]=1[NH2:31].[NH2:44][C:45]1[S:46][CH:47]=[CH:48][N:49]=1>>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:5]([C:6]([O:8][CH3:9])=[O:7])[C:4]=1[O:13][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N+:21]([O-:23])=[O:22].[CH3:24][O:25][C:26]1[CH:39]=[CH:38][CH:37]=[C:36]([C:40]([O:42][CH3:43])=[O:41])[C:27]=1[O:28][C:29]1[CH:35]=[CH:34][CH:33]=[CH:32][C:30]=1[NH:31][C:4]([NH:44][C:45]1[S:46][CH:47]=[CH:48][N:49]=1)=[O:13]