Hydrochloric Acid → HCID 86607188, compound

HRID 2276157Notes

Reaction equation

[CH:1]1([C:6]([C:8]2[CH:13]=[C:12]([CH3:14])[CH:11]=[CH:10][C:9]=2[NH:15][C:16](=[O:33])[NH:17][C:18]2[S:19][CH:20]=[C:21]([CH2:23][C:24]([N:26]3[CH2:31][CH2:30][N:29]([CH3:32])[CH2:28][CH2:27]3)=[O:25])[N:22]=2)=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:34]>>[Cl-:34].[CH:1]1([C:6]([C:8]2[CH:13]=[C:12]([CH3:14])[CH:11]=[CH:10][C:9]=2[NH:15][C:16](=[O:33])[NH:17][C:18]2[S:19][CH:20]=[C:21]([CH2:23][C:24]([N:26]3[CH2:31][CH2:30][NH+:29]([CH3:32])[CH2:28][CH2:27]3)=[O:25])[N:22]=2)=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 59732801HCID 59732801, compound

Product 1

HCID 86607188HCID 86607188, compound

Procedure

4-(2-{2-[3-(2-Cyclopentanecarbonyl-4-methylphenyl)-ureido]-thiazol-4-yl}-acetyl)-1-methyl-piperazinium chloride (392 mg) is prepared from 4-(2-{2-[3-(2-cyclopentanecarbonyl-4-methylphenyl)-ureido]-thiazol-4-yl}-acetyl)-1-methyl-piperazine (386 mg, 1.0 mmol) by treatment with anhydrous hydrogen chloride (5 ml, 4.0 M solution in dioxane) followed by collection of the solid product.

Workup

customfollowed by collection of the solid product

Sources & evidence

ORD record: ord-04f5112194344d9c87e7a4db4554e55e
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: USRE045670E1

Reaction notes

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