HCID 72369978, compound → HCID 72369988, compound

HRID 2276181Notes

Reaction equation

HRID 2276181 reaction equation
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][CH2:9][N:8]([CH2:12][CH2:13][C:14]2[N:15]=[C:16]([NH:19][C:20]([NH:22][C:23]3[CH:28]=[CH:27][C:26]([CH3:29])=[CH:25][C:24]=3[C:30]([CH:32]3[CH2:36][CH2:35][CH2:34][CH2:33]3)=[O:31])=[O:21])[S:17][CH:18]=2)[CH2:7]1)=[O:5])C>[Li+].[OH-]>[CH:32]1([C:30]([C:24]2[CH:25]=[C:26]([CH3:29])[CH:27]=[CH:28][C:23]=2[NH:22][C:20](=[O:21])[NH:19][C:16]2[S:17][CH:18]=[C:14]([CH2:13][CH2:12][N:8]3[CH2:9][CH2:10][CH2:11][CH:6]([C:4]([OH:5])=[O:3])[CH2:7]3)[N:15]=2)=[O:31])[CH2:36][CH2:35][CH2:34][CH2:33]1

Participants

3

Reactant 1

HCID 72369978HCID 72369978, compound

Product 1

HCID 72369988HCID 72369988, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 3939Lithium HydroxideSolvent

Procedure

1-(2-{2-[3-(2-Cyclopentanecarbonyl-4-methyl-phenyl)-ureido]-thiazol-4-yl}-ethyl)-piperidin-3-carboxylic acid (18 mg, 95%) was prepared from 1-(2-{2-[3-(2-cyclopentanecarbonyl-4-methyl-phenyl)-ureido]-thiazol-4-yl}-ethyl)-piperidin-3-carboxylic acid ethyl ester (0.02 g, 0.04 mmol) and 2.5M LiOH (20 uL) following the general procedure J.

Sources & evidence

ORD record
ord-28d17b529451401a90b8359691cd29c7
Source dataset
uspto-grants-2015_09
Patent number
USRE045670E1

Reaction notes

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