HCID 86593074, compound → HCID 59733074, compound

HRID 2276185Notes

Reaction equation

HRID 2276185 reaction equation
C([O:3][C:4](=[O:32])[CH2:5][NH:6][CH2:7][CH2:8][C:9]1[N:10]=[C:11]([NH:14][C:15]([NH:17][C:18]2[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][C:19]=2[C:25]([CH:27]2[CH2:31][CH2:30][CH2:29][CH2:28]2)=[O:26])=[O:16])[S:12][CH:13]=1)C>[Li+].[OH-]>[CH:27]1([C:25]([C:19]2[CH:20]=[C:21]([CH3:24])[CH:22]=[CH:23][C:18]=2[NH:17][C:15](=[O:16])[NH:14][C:11]2[S:12][CH:13]=[C:9]([CH2:8][CH2:7][NH:6][CH2:5][C:4]([OH:32])=[O:3])[N:10]=2)=[O:26])[CH2:31][CH2:30][CH2:29][CH2:28]1

Participants

3

Reactant 1

HCID 86593074HCID 86593074, compound

Product 1

HCID 59733074HCID 59733074, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 3939Lithium HydroxideSolvent

Procedure

(2-{-2-[3-(2-cyclopentanecarbonyl-4-methyl-phenyl)-ureido]-thiazol-4-yl}-ethyl amino)-acetic acid (18 mg, 95%) was prepared from (2-{-2-[3-(2-cyclopentanecarbonyl-4-methyl-phenyl)-ureido]-thiazol-4-yl}-ethyl amino)-acetic acid ethyl ester (0.02 g, 0.05 mmol) and 2.5M LiOH (20 uL) following the general procedure J.

Sources & evidence

ORD record
ord-cb8243ad70ed4d34b757c7a6a71ededd
Source dataset
uspto-grants-2015_09
Patent number
USRE045670E1

Reaction notes

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