2-Methoxyethylamine → HCID 59733005, compound

HRID 2276257Notes

Reaction equation

[CH2:1]([O:5][C:6]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:7]=1[NH:13][C:14](=[O:25])[NH:15][C:16]1[S:17][CH:18]=[C:19]([CH2:21][C:22]([OH:24])=O)[N:20]=1)[CH:2]([CH3:4])[CH3:3].[CH3:26][O:27][CH2:28][CH2:29][NH2:30]>>[CH2:1]([O:5][C:6]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:7]=1[NH:13][C:14](=[O:25])[NH:15][C:16]1[S:17][CH:18]=[C:19]([CH2:21][C:22]([NH:30][CH2:29][CH2:28][O:27][CH3:26])=[O:24])[N:20]=1)[CH:2]([CH3:3])[CH3:4]

Participants

Reactant 2

HCID 80182-Methoxyethylamine

HCID 59732755HCID 59732755, compound

Product 1

HCID 59733005HCID 59733005, compoundYield 62%

Procedure

2-{2-[3-(2-Isobutoxy-4-methyl-phenyl)-ureido]-thiazol-4-yl}-N-(2-methoxy-ethyl)-acetamide (130 mg, 62%) was prepared from {2-[3-(2-isobutoxy-4-methyl-phenyl)-ureido]-thiazol-4-yl}-acetic acid (181 mg, 0.5 mmol) and 2-methoxyethylamine following the general procedure K.

Sources & evidence

ORD record: ord-daafe43ac2e7460b975b252f4071bcef
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: USRE045670E1

Reaction notes

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