2-Aminothiazole → HCID 66999088, compound

HRID 2276264Notes

Reaction equation

HRID 2276264 reaction equation
[CH2:1]([NH2:5])[CH:2](C)C.FC1C=C(C)C=CC=1[N+]([O-])=[O:14].[CH2:17]([NH:21][C:22]1[CH:28]=[C:27]([CH3:29])[CH:26]=[CH:25][C:23]=1[NH2:24])[CH:18]([CH3:20])[CH3:19].N[C:31]1[S:32]C=[CH:34][N:35]=1>>[CH2:17]([NH:21][C:22]1[CH:28]=[C:27]([CH3:29])[CH:26]=[CH:25][C:23]=1[NH2:24])[CH:18]([CH3:20])[CH3:19].[CH2:17]([NH:21][C:22]1[CH:28]=[C:27]([CH3:29])[CH:26]=[CH:25][C:23]=1[NH:24][C:34]([NH:35][C:31]1[S:32][CH:2]=[CH:1][N:5]=1)=[O:14])[CH:18]([CH3:20])[CH3:19]

Participants

6

Reactant 4

HCID 21552-AminothiazoleHCID 6558IsobutylamineHCID 67966Benzene, 2-fluoro-4-methyl-1-nitro-HCID 66999088HCID 66999088, compound

Product 2

HCID 59732746HCID 59732746, compoundYield 65%HCID 66999088HCID 66999088, compoundYield 69%

Procedure

2-Isobutylamino-4-methyl-aniline (0.61 g, 69%) was prepared from isobutylamine (0.73 g, 10.0 mmol) and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure W. 1-(2-Isobutylamino-4-methyl-phenyl)-3-thiazol-2-yl-urea (196 mg, 65%) was prepared from 2-Isobutylamino-4-methyl-aniline (178 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.

Sources & evidence

ORD record
ord-a652594d5c05481da33d21d6d92429ed
Source dataset
uspto-grants-2015_09
Patent number
USRE045670E1

Reaction notes

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