Methylamine → HCID 59732692, compound

HRID 2276265Notes

Reaction equation

[CH2:1]([N:5]([CH3:26])[C:6]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:7]=1[NH:13][C:14](=[O:25])[NH:15][C:16]1[S:17][CH:18]=[C:19]([CH2:21][C:22]([OH:24])=O)[N:20]=1)[CH:2]([CH3:4])[CH3:3].[CH3:27][NH2:28]>>[CH2:1]([N:5]([CH3:26])[C:6]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:7]=1[NH:13][C:14](=[O:25])[NH:15][C:16]1[S:17][CH:18]=[C:19]([CH2:21][C:22]([NH:28][CH3:27])=[O:24])[N:20]=1)[CH:2]([CH3:3])[CH3:4]

Participants

Reactant 2

HCID 6329Methylamine

HCID 59733140HCID 59733140, compound

Product 1

HCID 59732692HCID 59732692, compoundYield 65%

Procedure

2-(2-{3-[2-(Isobutyl-methyl-amino)-4-methyl-phenyl]-ureido}-thiazol-4-yl)-N-methyl-acetamide (63 mg, 65%) was prepared from (2-{3-[2-(isobutyl-methyl-amino)-4-methyl-phenyl]-ureido}-thiazol-4-yl)-acetic acid (95 mg, 0.25 mmol) and methylamine following the general procedure K.

Sources & evidence

ORD record: ord-ae2498f026f2438cb670b370c121c1fd
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: USRE045670E1

Reaction notes

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