反应详情

A suspension of Example 337A (0.26 g) in methanol (5 mL) was stirred under a hydrogen atmosphere (balloon) in the presence of 10% Pd/C (100 mg) for 24 hours, and filtered through diatomaceous earth (Celite®). The pad was washed with methanol and the combined filtrates were concentrated and purified by silica gel chromatography with 7% methanol/dichloromethane to provide 0.127 g of the desired product. MS (ESI(+)) m/e 258 (M+H)+.

1. filtrationfiltered through diatomaceous earth (Celite®)
2. washThe pad was washed with methanol
3. concentrationthe combined filtrates were concentrated
4. custompurified by silica gel chromatography with 7% methanol/dichloromethane