5-(4-Nitrophenyl)thieno[2,3-d]pyrimidine-2,4-diamine → 5-(4-Aminophenyl)thieno[2,3-d]pyrimidine-2,4-diamine

Participants

Reaction Steps

A suspension of Example 337A (0.26 g) in methanol (5 mL) was stirred under a hydrogen atmosphere (balloon) in the presence of 10% Pd/C (100 mg) for 24 hours, and filtered through diatomaceous earth (Celite®). The pad was washed with methanol and the combined filtrates were concentrated and purified by silica gel chromatography with 7% methanol/dichloromethane to provide 0.127 g of the desired product. MS (ESI(+)) m/e 258 (M+H)+.

Provenance & Evidence