反应详情

A solution of intermediate D19 (0.43 g, 1.40 mmol) and N-chlorosuccinimide (0.19 g, 1.40 mmol) in DCM (10 ml) was stirred at room temperature for 1 hour. The solvent was evaporated in vacuo and the crude product was purified by column chromatography (silica gel; 0-3% methanol/DCM as eluent). The desired fractions were collected and evaporated in vacuo and the resulting solid was recrystallized from diethyl ether to yield compound E2 (0.39 g, 82%) as a white solid.

1. customThe solvent was evaporated in vacuo
2. customthe crude product was purified by column chromatography (silica gel; 0-3% methanol/DCM as eluent)
3. customThe desired fractions were collected
4. customevaporated in vacuo
5. customthe resulting solid was recrystallized from diethyl ether