Sodium Hydroxide → 2-(Trifluoromethyl)benzenecarbaldehyde oxime

HRID 2276392Notes

Reaction equation

HRID 2276392 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]=O.[OH-:13].[Na+].[NH2:15]O.Cl>C(O)C.O>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]=[N:15][OH:13]

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 123067o-(Trifluoromethyl)benzaldehydeHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 16173382-(Trifluoromethyl)benzenecarbaldehyde oximeYield 85.5%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent2×

Procedure

2-(trifluoromethyl)benzaldehyde (34.82 g, 200.0 mmol) was dissolved in ethanol (200 mL), and added with sodium hydroxide (12.00 g, 300.0 mmol) dissolved in purified water (50 mL). Hydrochloric acid hydroxylamine (16.68 g, 240 mmol) dissolved in purified water (50 mL) was added thereto, followed by stirring for 3 hours. After the reaction was completed, the resultant product was added with ice. The produced solid was filtered, washed with purified water (600 mL), and dried so as to provide a white solid required compound (32.15 g, 171 mmol, 85%).

Workup

  1. additionwas added
  2. filtrationThe produced solid was filtered
  3. washwashed with purified water (600 mL)
  4. customdried so as

Sources & evidence

ORD record
ord-ddffcd3f011844c6b60b501946c87e0b
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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