Sodium Hydroxide → p-Trifluoromethoxybenzaldehyde oxime

HRID 2276393Notes

Reaction equation

HRID 2276393 reaction equation
[F:1][C:2]([F:13])([F:12])[O:3][C:4]1[CH:11]=[CH:10][C:7]([CH:8]=O)=[CH:6][CH:5]=1.[OH-:14].[Na+].[NH2:16]O.Cl>>[F:1][C:2]([F:13])([F:12])[O:3][C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[N:16][OH:14])=[CH:6][CH:5]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 69573p-(Trifluoromethoxy)benzaldehydeHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 2777199p-Trifluoromethoxybenzaldehyde oximeYield 94%

Procedure

In a similar manner as described in Preparation Example 1, by using 4-(trifluoromethoxy)benzaldehyde (38.02 g, 200.0 mmol), sodium hydroxide (12.00 g, 300.0 mmol) and hydrochloric acid hydroxylamine (16.68 g, 240 mmol), a white solid required compound (38.68 g, 188 mmol, 94%) was obtained.

Workup

  1. customIn a similar manner as described in Preparation Example 1

Sources & evidence

ORD record
ord-2d1b21b657f145ceb454501707d3938c
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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