Sodium Hydroxide → HCID 73014310, compound

HRID 2276396Notes

Reaction equation

HRID 2276396 reaction equation
[F:1][C:2]([F:13])([F:12])[O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH:7]=O.[OH-:14].[Na+].[NH2:16]O.Cl>>[F:1][C:2]([F:13])([F:12])[O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH:7]=[N:16][OH:14]

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 6051393-(Trifluoromethoxy)benzaldehyde

Product 1

HCID 73014310HCID 73014310, compoundYield 97%

Procedure

In a similar manner as described in Preparation Example 1, by using 3-(trifluoromethoxy)benzaldehyde (38.03 g, 200.0 mmol), sodium hydroxide (12.00 g, 300.0 mmol) and hydrochloric acid hydroxylamine (16.6 g, 240 mmol), a white solid required compound (39.74 g, 193 mmol, 97%) was obtained.

Workup

  1. customIn a similar manner as described in Preparation Example 1

Sources & evidence

ORD record
ord-deff5836d8ba4914990fdb866584e96b
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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