Sodium Hydroxide → 4-Isoxazolecarboxylic acid, 3-(2-chlorophenyl)-5-methyl-

HRID 2276408Notes

Reaction equation

HRID 2276408 reaction equation
C[O:2][C:3]([C:5]1[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[Cl:17])=[N:7][O:8][C:9]=1[CH3:10])=[O:4].[OH-].[Na+]>CO>[Cl:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[C:6]1[C:5]([C:3]([OH:4])=[O:2])=[C:9]([CH3:10])[O:8][N:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 2763469Methyl 3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carboxylate

Product 1

HCID 902034-Isoxazolecarboxylic acid, 3-(2-chlorophenyl)-5-methyl-Yield 90%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described in Preparation Example 25, by using methanol (60 mL), methyl-3-(2-chlorophenyl)-5-methylisoxazol-4-carboxylate (6.0 g, 23.84 mmol) and 3% sodium hydroxide aqueous solution (60 mL), a white solid required compound (5.10 g, 21.44 mmol, 90%) was obtained.

Workup

  1. customIn a similar manner as described in Preparation Example 25

Sources & evidence

ORD record
ord-e362b38f9c1c497291723a556e12f8d8
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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