HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-Isoxazolecarboxylic acid, 3-(2-chlorophenyl)-5-methyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carboxylate | HCID 2763469 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Isoxazolecarboxylic acid, 3-(2-chlorophenyl)-5-methyl- | HCID 90203 | 90% |
Reaction Steps
In a similar manner as described in Preparation Example 25, by using methanol (60 mL), methyl-3-(2-chlorophenyl)-5-methylisoxazol-4-carboxylate (6.0 g, 23.84 mmol) and 3% sodium hydroxide aqueous solution (60 mL), a white solid required compound (5.10 g, 21.44 mmol, 90%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09132126B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-e362b38f9c1c497291723a556e12f8d8 |
| Source note | uspto-grants-2015_09 |