Methyl cyanoacetate → HCID 70982357, compound

HRID 2276415Notes

Reaction equation

HRID 2276415 reaction equation
[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]([F:13])([F:12])[F:11].[CH3:15][O:16][C:17](=[O:21])[CH2:18][C:19]#[N:20].C[O-].[Na+]>CO>[CH3:15][O:16][C:17]([C:18]1[C:3]([C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[C:10]([F:13])([F:12])[F:11])=[N:2][O:1][C:19]=1[NH2:20])=[O:21]

Participants

5

Reactant 3

HCID 7747Methyl cyanoacetateHCID 10942334Sodium MethoxideHCID 53395456N-Hydroxy-2-(trifluoromethyl)benzene-1-carboximidoyl chloride

Product 1

HCID 70982357HCID 70982357, compoundYield 85.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described in Preparation Example 17, by using methanol (160 mL), N-hydroxy-2-(trifluoromethyl)benzimidoyl chloride (8.00 g, 33.39 mmol), methylcyanoacetate (4.14 g, 41.74 mmol) and sodium methoxide (3.61 g, 66.78 mmol), a white solid required compound (8.13 g, 28.42 mmol, 85%) was obtained.

Workup

  1. customIn a similar manner as described in Preparation Example 17

Sources & evidence

ORD record
ord-7f61e1c883a9422d86daea1909661a32
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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