Methyl cyanoacetate → HCID 70980612, compound

HRID 2276421Notes

Reaction equation

HRID 2276421 reaction equation
[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:13])([F:12])[F:11])[CH:5]=1.[CH3:15][O:16][C:17](=[O:21])[CH2:18][C:19]#[N:20].C[O-].[Na+]>CO>[CH3:15][O:16][C:17]([C:18]1[C:3]([C:4]2[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:13])([F:12])[F:11])[CH:5]=2)=[N:2][O:1][C:19]=1[NH2:20])=[O:21]

Participants

5

Reactant 3

HCID 7747Methyl cyanoacetateHCID 10942334Sodium MethoxideHCID 85444714HCID 85444714, compound

Product 1

HCID 70980612HCID 70980612, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described in Preparation Example 17, by using methanol (160 mL), N-hydroxy-3-(trifluoromethyl)benzimidoylchloride (8.00 g, 33.39 mmol), methylcyanoacetate (4.14 g, 41.74 mmol) and sodium methoxide (3.61 g, 66.78 mmol), a white solid required compound (7.46 g, 26.06 mmol, 78%) was obtained.

Workup

  1. customIn a similar manner as described in Preparation Example 17

Sources & evidence

ORD record
ord-3e2dee40aa2f41799251d01445205e5a
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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