Sodium Hydroxide → HCID 70980423, compound

HRID 2276423Notes

Reaction equation

HRID 2276423 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[C:13]([F:16])([F:15])[F:14])[C:3]=1[C:17]([O-:19])=[O:18].[OH-].[Na+]>CO>[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[C:13]([F:16])([F:15])[F:14])[C:3]=1[C:17]([OH:19])=[O:18]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86709607HCID 86709607, compound

Product 1

HCID 70980423HCID 70980423, compoundYield 71.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described in Preparation Example 25, by using methanol (60 mL), 5-amino-3-(2-(trifluoromethyl)phenyl)isoxazol-4-carboxylate (6.0 g, 20.96 mmol) and 3% sodium hydroxide aqueous solution (60 mL), a white solid required compound (4.06 g, 14.92 mmol, 71%) was obtained.

Workup

  1. customIn a similar manner as described in Preparation Example 25

Sources & evidence

ORD record
ord-42e1eb8975754849854421222566b292
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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