Sodium Hydroxide → 5-Amino-3-(2-fluorophenyl)isoxazol-4-carboxylic acid

HRID 2276426Notes

Reaction equation

HRID 2276426 reaction equation
C[O:2][C:3]([C:5]1[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[F:17])=[N:7][O:8][C:9]=1[NH2:10])=[O:4].[OH-].[Na+]>CO>[NH2:10][C:9]1[O:8][N:7]=[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[F:17])[C:5]=1[C:3]([OH:4])=[O:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 70982071Methyl-5-amino-3-(2-fluorophenyl)isoxazol-4-carboxylate

Product 1

HCID 709812185-Amino-3-(2-fluorophenyl)isoxazol-4-carboxylic acidYield 56.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described in Preparation Example 25, by using methanol (60 mL), methyl-5-amino-3-(2-fluorophenyl)isoxazol-4-carboxylate (6.0 g, 25.40 mmol) and 3% sodium hydroxide aqueous solution (60 mL), a white solid required compound (3.18 g, 14.33 mmol, 56%) was obtained.

Workup

  1. customIn a similar manner as described in Preparation Example 25

Sources & evidence

ORD record
ord-a868edc5cd894e40a3ab47c327777ef3
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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