HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 5-Amino-3-(2-fluorophenyl)isoxazol-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl-5-amino-3-(2-fluorophenyl)isoxazol-4-carboxylate | HCID 70982071 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Amino-3-(2-fluorophenyl)isoxazol-4-carboxylic acid | HCID 70981218 | 56.4% |
Reaction Steps
In a similar manner as described in Preparation Example 25, by using methanol (60 mL), methyl-5-amino-3-(2-fluorophenyl)isoxazol-4-carboxylate (6.0 g, 25.40 mmol) and 3% sodium hydroxide aqueous solution (60 mL), a white solid required compound (3.18 g, 14.33 mmol, 56%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09132126B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-a868edc5cd894e40a3ab47c327777ef3 |
| Source note | uspto-grants-2015_09 |