Sodium Hydroxide → HCID 70982325, compound

HRID 2276430Notes

Reaction equation

HRID 2276430 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([O:13][C:14]([F:17])([F:16])[F:15])[CH:8]=2)[C:3]=1[C:18]([O:20]C)=[O:19].[OH-].[Na+]>CO>[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([O:13][C:14]([F:16])([F:17])[F:15])[CH:8]=2)[C:3]=1[C:18]([OH:20])=[O:19]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 70981114HCID 70981114, compound

Product 1

HCID 70982325HCID 70982325, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described in Preparation Example 25, by using methanol (60 mL), methyl 5-amino-3-(3-(trifluoromethoxy)phenyl)isoxazol-4-carboxylate (6.0 g, 19.85 mmol) and 3% sodium hydroxide aqueous solution (60 mL), a white solid required compound (4.16 g, 14.43 mmol, 73%) was obtained.

Workup

  1. customIn a similar manner as described in Preparation Example 25

Sources & evidence

ORD record
ord-95e95bc10b914c1da6a35c62dadc53fa
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

Loading…