N-(3-methoxyphenyl)piperazine → HCID 9273577, compound

HRID 2276437Notes

Reaction equation

HRID 2276437 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:12]([C:13]([OH:15])=O)=[C:11]([CH3:16])[O:10][N:9]=1.Cl.C(N=C=NCCCN(C)C)C.[CH3:29][O:30][C:31]1[CH:32]=[C:33]([N:37]2[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]2)[CH:34]=[CH:35][CH:36]=1>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:12]([C:13]([N:40]2[CH2:39][CH2:38][N:37]([C:33]3[CH:34]=[CH:35][CH:36]=[C:31]([O:30][CH3:29])[CH:32]=3)[CH2:42][CH2:41]2)=[O:15])=[C:11]([CH3:16])[O:10][N:9]=1

Participants

5

Reactant 3

HCID 81430N-(3-methoxyphenyl)piperazineHCID 902034-Isoxazolecarboxylic acid, 3-(2-chlorophenyl)-5-methyl-HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

Product 1

HCID 9273577HCID 9273577, compoundYield 76.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a similar manner as described in Example 1, by using dichloromethane (30 mL), 3-(2-chlorophenyl)-5-methylisoxazol-4-carboxylic acid (437 mg, 1.84 mmol), 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride (388 mg, 2.02 mmol) and 1-(3-methoxyphenyl)piperazine (354 mg, 1.84 mmol), a white solid required compound (576 mg, 1.40 mmol, 76%) was obtained.

Sources & evidence

ORD record
ord-b3614938138c41cfb3df0bcb6fa0c74a
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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