1-(3-(Trifluoromethyl)phenyl)piperazine → HCID 86709609, 화합물

HRID 2276486노트

반응식

HRID 2276486 반응식
[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[O:13][C:14]([F:17])([F:16])[F:15])[C:3]=1[C:18]([OH:20])=O.Cl.C(N=C=NCCCN(C)C)C.[F:33][C:34]([F:48])([F:47])[C:35]1[CH:36]=[C:37]([N:41]2[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]2)[CH:38]=[CH:39][CH:40]=1>ClCCl>[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[O:13][C:14]([F:15])([F:16])[F:17])[C:3]=1[C:18]([N:44]1[CH2:43][CH2:42][N:41]([C:37]2[CH:38]=[CH:39][CH:40]=[C:35]([C:34]([F:47])([F:48])[F:33])[CH:36]=2)[CH2:46][CH2:45]1)=[O:20]

참가 물질

5

반응물 3

HCID 42961-(3-(Trifluoromethyl)phenyl)piperazineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 70981175HCID 70981175, 화합물

생성물 1

HCID 86709609HCID 86709609, 화합물수율 69%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In a similar manner as described in Example 1, by using dichloromethane (30 mL), 5-amino-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-carboxylic acid (530 mg, 1.84 mmol), 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride (388 mg, 2.02 mmol) and 1-(3-(trifluoromethyl)phenyl)piperazine (424 mg, 1.84 mmol), a white solid required compound (633 mg, 1.27 mmol, 69%) was obtained.

출처 및 근거

ORD 기록
ord-e7b41fc5d1d943adbd963005bece4e28
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09132126B2

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