HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 66576460, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 1-Piperazinecarboxylic acid, ethyl ester | HCID 8431 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 28812093 | HCID 28812093 | — |
| Product | HCID 66576460 | HCID 66576460 | 60% |
Reaction Steps
In a similar manner as described in Example 1, by using dichloromethane (30 mL), 5-amino-3-(2-chlorophenyl)isoxazol-4-carboxylic acid (439 mg, 1.84 mmol), 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride (388 mg, 2.02 mmol) and ethyl piperazine-4-carboxylate (289 mg, 1.84 mmol), a white solid required compound (422 mg, 1.12 mmol, 60%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09132126B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-af4caf1f91bd4b708286125ed66abab7 |
| Source note | uspto-grants-2015_09 |