Dichloromethane → HCID 66576460, compound

HRID 2276504Notes

Reaction equation

HRID 2276504 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[Cl:13])[C:3]=1[C:14]([OH:16])=O.Cl.C(N=C=N[CH2:23][CH2:24][CH2:25][N:26]([CH3:28])C)C.N1CCN([C:35]([O:37][CH2:38][CH3:39])=[O:36])CC1.Cl[CH2:41]Cl>>[CH2:38]([O:37][C:35]([CH:23]1[CH2:24][CH2:25][N:26]([C:14]([C:3]2[C:4]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[Cl:13])=[N:5][O:6][C:2]=2[NH2:1])=[O:16])[CH2:28][CH2:41]1)=[O:36])[CH3:39]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 84311-Piperazinecarboxylic acid, ethyl esterHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 28812093HCID 28812093, compound

Product 1

HCID 66576460HCID 66576460, compoundYield 60%

Procedure

In a similar manner as described in Example 1, by using dichloromethane (30 mL), 5-amino-3-(2-chlorophenyl)isoxazol-4-carboxylic acid (439 mg, 1.84 mmol), 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride (388 mg, 2.02 mmol) and ethyl piperazine-4-carboxylate (289 mg, 1.84 mmol), a white solid required compound (422 mg, 1.12 mmol, 60%) was obtained.

Sources & evidence

ORD record
ord-af4caf1f91bd4b708286125ed66abab7
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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