Dichloromethane → HCID 70981925, compound

HRID 2276505Notes

Reaction equation

HRID 2276505 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[F:13])[C:3]=1[C:14]([OH:16])=O.Cl.C(N=C=N[CH2:23][CH2:24][CH2:25][N:26]([CH3:28])C)C.N1CCN([C:35]([O:37][CH3:38])=[O:36])CC1.Cl[CH2:40]Cl>>[CH3:38][O:37][C:35]([CH:23]1[CH2:24][CH2:25][N:26]([C:14]([C:3]2[C:4]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[F:13])=[N:5][O:6][C:2]=2[NH2:1])=[O:16])[CH2:28][CH2:40]1)=[O:36]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 142729Methyl piperazine-1-carboxylateHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 709812185-Amino-3-(2-fluorophenyl)isoxazol-4-carboxylic acid

Product 1

HCID 70981925HCID 70981925, compoundYield 72%

Procedure

In a similar manner as described in Example 1, by using dichloromethane (30 mL), 5-amino-3-(2-fluorophenyl)isoxazol-4-carboxylic acid (409 mg, 1.84 mmol), 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride (388 mg, 2.02 mmol) and methyl piperazine-4-carboxylate (263 mg, 1.84 mmol), a white solid required compound (463 mg, 1.33 mmol, 72%) was obtained.

Sources & evidence

ORD record
ord-6d5f48b3f36841f79027555d99a0c010
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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