Ethanol → HCID 86709611, compound

HRID 2276506Notes

Reaction equation

HRID 2276506 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[C:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[O:29][C:30]([F:33])([F:32])[F:31])=[N:19][O:20][C:21]=3[CH3:22])=[O:16])[CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].C(O)C>CC(C)=O>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[C:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[O:29][C:30]([F:33])([F:32])[F:31])=[N:19][O:20][C:21]=3[CH3:22])=[O:16])[CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 702EthanolHCID 66575833HCID 66575833, compound

Product 1

HCID 86709611HCID 86709611, compoundYield 1,200%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
0 °C

Procedure

(4-(3,4-dichlorophenyl)piperazine-1-yl)(5-methyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methanone (100 mg, 0.20 mmol) was dissolved in acetone (10 mL), cooled to 0° C. and slowly added with hydrochloric ethanol (10%, 73 mg, 0.20 mmol). The resultant product was stirred at room temperature for 8 hours, filtered, and dried so as to provide a white solid required compound (84 mg, 1.20 mmol, 78%).

Workup

  1. filtrationfiltered
  2. customdried so as

Sources & evidence

ORD record
ord-beccec944c33481e879e6afd09c6b7c2
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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