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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 227655Generated: October 30, 2026

Diethyl bromomalonate → 5-Thiazolecarboxylicacid,2-amino-4-hydroxy-,ethylester(9CI)

https://huagongshe.com/reaction/227655

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethyl bromomalonateHCID 69637—
ReactantThioureaHCID 2723790—
Product5-Thiazolecarboxylicacid,2-amino-4-hydroxy-,ethylester(9CI)HCID 224465—

Reaction Steps

Prepared according to literature procedure (Baldwin, J. J., et al. J. Med. Chem. 1980, 23, 65-70.) from thiourea and diethyl bromomalonate. MS m/z 189 (m+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07560568B2
Source datasetuspto-grants-2009_07
ORD IDord-3162e93119ca424ca91ab75237bc2af3
Source noteuspto-grants-2009_07