Diethyl bromomalonate → 5-Thiazolecarboxylicacid,2-amino-4-hydroxy-,ethylester(9CI)

HRID 227655Notes

Reaction equation

[NH2:1][C:2]([NH2:4])=[S:3].Br[CH:6]([C:12](OCC)=[O:13])[C:7]([O:9][CH2:10][CH3:11])=[O:8]>>[NH2:1][C:2]1[S:3][C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[C:12]([OH:13])[N:4]=1

Participants

Reactant 2

HCID 69637Diethyl bromomalonate

HCID 2723790Thiourea

Product 1

HCID 2244655-Thiazolecarboxylicacid,2-amino-4-hydroxy-,ethylester(9CI)

Procedure

Prepared according to literature procedure (Baldwin, J. J., et al. J. Med. Chem. 1980, 23, 65-70.) from thiourea and diethyl bromomalonate. MS m/z 189 (m+1).

Workup

customPrepared

Sources & evidence

ORD record: ord-3162e93119ca424ca91ab75237bc2af3
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07560568B2

Reaction notes

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