Hydrochloric Acid → HCID 66666112, compound

HRID 2276550Notes

Reaction equation

HRID 2276550 reaction equation
C([O:4][CH:5]1[C:14]2[C:9](=[N:10][C:11]([C:22]3[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][CH:23]=3)=[C:12]([C:15]3[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=3)[N:13]=2)[N:8]([CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][C:35]([O:37]CC)=[O:36])[CH2:7][CH2:6]1)(=O)C.[OH-].[Na+].Cl>C(O)C>[OH:4][CH:5]1[C:14]2[C:9](=[N:10][C:11]([C:22]3[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][CH:23]=3)=[C:12]([C:15]3[CH:16]=[CH:17][C:18]([CH3:21])=[CH:19][CH:20]=3)[N:13]=2)[N:8]([CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][C:35]([OH:37])=[O:36])[CH2:7][CH2:6]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 131731626HCID 131731626, compound

Product 1

HCID 66666112HCID 66666112, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To rac-ethyl 7-(8-acetoxy-2,3-dip-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate (step 1) (75 mg, 0.142 mmol) in ethanol (2 ml) was added 2M sodium hydroxide (0.283 ml, 0.566 mmol). The reaction mixture was stirred at room temperature for 18 hours. The mixture was acidified with 2M HCl (0.283 ml) and the solvent was removed in vacuo. To the residue was added DCM and water. The organic portion was separated, dried (MgSO4), filtered and concentrated in vacuo to afford the title compound;

Workup

  1. customthe solvent was removed in vacuo
  2. additionTo the residue was added DCM and water
  3. customThe organic portion was separated
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-698789ee188146cb901e62a4ee383011
Source dataset
uspto-grants-2015_09
Patent number
US09132127B2

Reaction notes

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