Hydrochloric Acid → HCID 12132292, compound

HRID 2276650Notes

Reaction equation

HRID 2276650 reaction equation
[CH3:1][O:2][C:3]1[CH:25]=[CH:24][CH:23]=[CH:22][C:4]=1[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13](=[O:21])[CH2:14][CH2:15][C:16]([O:18]CC)=[O:17])=[CH:9][CH:8]=1.[OH-].[Na+].Cl>C(O)C>[CH3:1][O:2][C:3]1[CH:25]=[CH:24][CH:23]=[CH:22][C:4]=1[CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([C:13](=[O:21])[CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:11][CH:12]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 21964526Ethyl 4-(4-(2-methoxybenzyloxy)phenyl)-4-oxobutyrate

Product 1

HCID 12132292HCID 12132292, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of Ethyl 4-(4-(2-methoxybenzyloxy)phenyl)-4-oxobutyrate (Step B, 1.49 g, 4.3 mmol) in abs ethanol (20 ml) was treated with 1N NaOH (6 ml). The reaction mixture was stirred at room temperature for 2 hours and then acidified with 1M HCl. The resulting white solid was filtered, washed with cold water and dried under vacuum to provide the title compound.

Workup

  1. filtrationThe resulting white solid was filtered
  2. washwashed with cold water
  3. customdried under vacuum

Sources & evidence

ORD record
ord-0b8f81e343394df2a45d4ee9c4a1f5b8
Source dataset
uspto-grants-2015_09
Patent number
US09133073B2

Reaction notes

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