反应详情

The solution of tert-Butyl (2-(7-((3-hydroxyphenyl)amino)-7-oxoheptanamido)phenyl)carbamate in EtOAc was stirred at 0° C. and bubbled with HCl gas for 20 min. The pH value of the solution was adjusted to 6 by saturated aqueous solution of Na2CO3. The aqueous phase was extracted with EtOAc (100 mL). The organic layers were combined and dried over Na2SO4 and then concentrated to give the crude product. The crude product was purified by flash chromatography SiO2 (EtOAc) to give desired compound CC No. 2 (0.25 g, yield 25.7%).

1. custombubbled with HCl gas for 20 min
2. extractionThe aqueous phase was extracted with EtOAc (100 mL)
3. dry with materialdried over Na2SO4
4. concentrationconcentrated
5. customto give the crude product
6. customThe crude product was purified by flash chromatography SiO2 (EtOAc)