Bromoform → HCID 86686827, compound

HRID 2276785Notes

Reaction equation

HRID 2276785 reaction equation
N[C:2]1[N:3]=[N:4][C:5]([C:8]2[S:9][C:10]([C:13]#[N:14])=[CH:11][N:12]=2)=[CH:6][N:7]=1.N(OCCC(C)C)=O.C(Br)(Br)[Br:24]>>[Br:24][C:2]1[N:3]=[N:4][C:5]([C:8]2[S:9][C:10]([C:13]#[N:14])=[CH:11][N:12]=2)=[CH:6][N:7]=1

Participants

4

Reactant 3

HCID 5558BromoformHCID 8053Isoamyl NitriteHCID 67452356HCID 67452356, compound

Product 1

HCID 86686827HCID 86686827, compound

Conditions

Temperature
90 °C

Procedure

2-(3-Amino-1,2,4-triazin-6-yl)thiazole-5-carbonitrile (30 mg, 0.15 mmol) was dissolved in 1 mL of bromoform and heated to 90° C. Isoamyl nitrite (88 mg, 0.75 mmol) was added and stirred at 90° C. for 2 h. The reaction mixture was then concentrated and used directly in the next reaction.

Workup

  1. concentrationThe reaction mixture was then concentrated
  2. customused directly in the next reaction

Sources & evidence

ORD record
ord-ea4a86421791435ab11310970e004d03
Source dataset
uspto-grants-2015_09
Patent number
US09133123B2

Reaction notes

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