Pyrrolidine → HCID 57756869, compound

HRID 227679Notes

Reaction equation

[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:6]([C:9]1[NH:13][CH:12]=[C:11]([C:14]([O:16]CC)=O)[C:10]=1[C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:26]([NH:28][C:29]2[CH:34]=[C:33]([C:35]([F:38])([F:37])[F:36])[CH:32]=[CH:31][C:30]=2[F:39])=[O:27])=[CH:21][CH:20]=1)(=[O:8])[NH2:7]>>[F:39][C:30]1[CH:31]=[CH:32][C:33]([C:35]([F:36])([F:37])[F:38])=[CH:34][C:29]=1[NH:28][C:26](=[O:27])[NH:25][C:22]1[CH:21]=[CH:20][C:19]([C:10]2[C:11]([C:14]([N:1]3[CH2:5][CH2:4][CH2:3][CH2:2]3)=[O:16])=[CH:12][NH:13][C:9]=2[C:6]([NH2:7])=[O:8])=[CH:24][CH:23]=1

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 57756911HCID 57756911, compound

Product 1

HCID 57756869HCID 57756869, compound

Procedure

The process is performed in a manner similar to that described in Example 39 but starting with pyrrolidine and ethyl 5-carbamoyl-4-{4-[3-(2-fluoro-5-trifluoromethylphenyl)ureido]phenyl}-1H-pyrrole-3-carboxylate. After a similar work-up, 3-{4-[3-(2-fluoro-5-trifluoromethylphenyl)ureido]phenyl}-4-(pyrrolidine-1-carbonyl)-1H-pyrrole-2-carboxamide is obtained; ES+: m/z=504 [M+H]+.

Sources & evidence

ORD record: ord-1958a45b69024375aa511391f6d9232b
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07560571B2

Reaction notes

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