Methyl bromoacetate → HCID 67296523, compound

HRID 2276844Notes

Reaction equation

HRID 2276844 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[CH2:12][CH2:11][C:10](=[O:13])[CH2:9]2)=[CH:4][CH:3]=1.Br[CH2:15][C:16]([O:18][CH3:19])=[O:17]>>[CH3:19][O:18][C:16](=[O:17])[CH2:15][O:1][C:2]1[CH:3]=[CH:4][C:5]([C@@H:8]2[CH2:12][CH2:11][C:10](=[O:13])[CH2:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 60984Methyl bromoacetateHCID 59617201HCID 59617201, compound

Product 1

HCID 67296523HCID 67296523, compoundYield 100.7%

Procedure

(R)-3-(4-Hydroxyphenyl)cyclopentanone (0.82 g, 4.6 mmol) and methyl bromoacetate (0.9 mL, 10 mmol) were used and treated in a similar manner to (Step 4) of (Example 10) to give the title compound (1.15 g, 100%).

Workup

  1. additiontreated in a similar manner to (Step 4) of (Example 10)

Sources & evidence

ORD record
ord-d1b54ecc22a44b3ab21cd9ecf11634a7
Source dataset
uspto-grants-2015_09
Patent number
US09133140B2

Reaction notes

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