HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (S)-3-Amino-5-phenyl-1-(5-chloropyridin-2-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Benzyl (2-oxo-5-phenyl-2,3-dihydro-1h-benzo[e][1,4]diazepin-3-yl)carbamate | HCID 2756242 | — |
| Reactant | 5-Chloro-2-iodopyridine | HCID 11118148 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | (S)-3-Amino-5-phenyl-1-(5-chloropyridin-2-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one | HCID 90080293 | — |
Reaction Steps
Intermediate B-16 was prepared from benzyl 2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate and 5-chloro-2-iodopyridine according to the procedure described for Intermediate B-15. RT=2.430 min (H2O/CH3OH with TFA, CHROMOLITH® ODS S5 4.6×50 mm, gradient=3 min, wavelength=220 and 254 nm); MS(ES):m/z=363.12 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133139B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-cc96c08f77794b75a1087ac1505ad827 |
| Source note | uspto-grants-2015_09 |